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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2A
All Species:
16.36
Human Site:
T518
Identified Species:
27.69
UniProt:
Q9BY44
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BY44
NP_114414.2
585
64990
T518
P
T
P
A
P
Q
S
T
P
R
N
T
V
S
Q
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001108004
580
64436
T513
P
T
P
A
P
Q
S
T
P
R
N
T
I
S
Q
Dog
Lupus familis
XP_534306
585
65159
T518
P
T
P
A
P
Q
S
T
P
R
N
T
I
S
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8BJW6
581
64385
A514
P
T
P
V
P
Q
S
A
P
R
N
T
V
T
Q
Rat
Rattus norvegicus
NP_001102809
541
60196
K494
P
E
V
D
K
K
I
K
N
L
K
K
K
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507598
493
54394
K446
P
E
V
D
K
K
I
K
N
L
R
K
K
L
K
Chicken
Gallus gallus
Q5ZKC1
586
64485
T519
Q
S
S
A
S
Q
N
T
P
R
S
A
V
P
V
Frog
Xenopus laevis
Q7ZY11
582
64798
T519
S
T
N
V
Q
N
N
T
P
V
A
V
N
T
G
Zebra Danio
Brachydanio rerio
Q4QRJ7
580
64206
H518
A
D
P
A
P
V
S
H
V
T
S
S
C
G
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VNX8
638
70052
P569
P
D
N
A
A
D
Q
P
P
N
S
Y
G
Q
G
Honey Bee
Apis mellifera
XP_625143
577
65273
L515
T
S
T
E
T
Q
N
L
T
T
N
V
P
E
C
Nematode Worm
Caenorhab. elegans
Q19052
570
64001
S518
Q
P
F
R
P
Q
Q
S
E
Q
E
R
K
A
F
Sea Urchin
Strong. purpuratus
XP_001186352
299
33040
V251
I
C
A
P
R
L
R
V
G
N
G
F
K
I
W
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53235
642
71286
S572
P
D
S
T
P
A
P
S
A
P
A
S
T
N
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.4
96
N.A.
92.8
82.5
N.A.
74.5
84.4
74.8
69.5
N.A.
39
43.9
35.7
29.2
Protein Similarity:
100
N.A.
98.2
98.2
N.A.
95.5
87
N.A.
79.4
91.6
86.5
81.5
N.A.
56.5
61.3
54.8
40
P-Site Identity:
100
N.A.
93.3
93.3
N.A.
80
6.6
N.A.
6.6
40
20
26.6
N.A.
20
13.3
13.3
0
P-Site Similarity:
100
N.A.
100
100
N.A.
86.6
20
N.A.
20
60
33.3
40
N.A.
26.6
26.6
33.3
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
45.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
43
8
8
0
8
8
0
15
8
0
8
8
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
8
% C
% Asp:
0
22
0
15
0
8
0
0
0
0
0
0
0
0
8
% D
% Glu:
0
15
0
8
0
0
0
0
8
0
8
0
0
8
0
% E
% Phe:
0
0
8
0
0
0
0
0
0
0
0
8
0
0
8
% F
% Gly:
0
0
0
0
0
0
0
0
8
0
8
0
8
8
15
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
15
0
0
0
0
0
15
8
0
% I
% Lys:
0
0
0
0
15
15
0
15
0
0
8
15
29
0
15
% K
% Leu:
0
0
0
0
0
8
0
8
0
15
0
0
0
15
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
15
0
0
8
22
0
15
15
36
0
8
8
0
% N
% Pro:
58
8
36
8
50
0
8
8
50
8
0
0
8
8
0
% P
% Gln:
15
0
0
0
8
50
15
0
0
8
0
0
0
8
29
% Q
% Arg:
0
0
0
8
8
0
8
0
0
36
8
8
0
0
0
% R
% Ser:
8
15
15
0
8
0
36
15
0
0
22
15
0
22
0
% S
% Thr:
8
36
8
8
8
0
0
36
8
15
0
29
8
15
0
% T
% Val:
0
0
15
15
0
8
0
8
8
8
0
15
22
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _